Grimrock

Attempting to start the game with DPI set to 150% resulted in a crash on start for me. Disabling display scaling in compatibility fixed it. Oddly, the game starts fine afterwards even if display scaling isn't disabled; perhaps it messes with the auto-detection on first run?

Not sure if it's the same problem I had, but try right clicking on the game shortcut then "properties" and check "Disable display scaling on high DPI settings" in the compatibility tab and apply.